LCZ696 (Valsartan)

Catalog No. A14206

LCZ696 (Valsartan)是一种生物利用型双效血管紧张素受体-中性溶血素抑制剂（ARNi），用于治疗高血压和心力衰竭。

Technical details

Catalog Num	A14206
M. Wt	915.98
Formula	C24H29N5O3.C24H29NO5.5/2H2O.3Na
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	936623-90-4
Synonyms	LCZ 696, LCZ-696
SMILES	CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)[C@@H](C(C)C)C(=O)O.CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O.O.O.O.[Na+].[Na+].[Na+]

Biological Activity

LCZ696 (Valsartan)是一种生物利用型双效血管紧张素受体-中性溶血素抑制剂（ARNi），用于治疗高血压和心力衰竭。

Targets

RAAS

Solubility *

In vitro	DMSO	Warmed: 26 mg/mL (28.38 mM)
	Water	Warmed: 88 mg/mL (96.07 mM)
	Ethanol	Warmed: 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	10.92 mL	54.59 mL	109.17 mL
0.5 mM	2.18 mL	10.92 mL	21.83 mL
1 mM	1.09 mL	5.46 mL	10.92 mL
5 mM	0.22 mL	1.09 mL	2.18 mL

*The above data is based on the productmolecular weight 915.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.