UMI-77

Catalog No. A14222

UMI-77是一种选择性的Mcl-1抑制剂，Ki为490 nM，显示出对Bcl-2家族其他成员的选择性。

Technical details

Catalog Num	A14222
M. Wt	468.34
Formula	C18H14BrNO5S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	518303-20-3
Synonyms	UMI 77,UMI77
SMILES	C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=C(C=C3)Br

Biological Activity

UMI-77是一种选择性的Mcl-1抑制剂，Ki为490 nM，显示出对Bcl-2家族其他成员的选择性。

Targets

Mcl-1
490 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	92 mg/mL (196.43 mM)
	Water	Insoluble
	Ethanol	Warmed: 92 mg/mL (196.43 mM)
In vivo	5% DMSO+30% PEG 300+dd H2O	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.35 mL	106.76 mL	213.52 mL
0.5 mM	4.27 mL	21.35 mL	42.7 mL
1 mM	2.14 mL	10.68 mL	21.35 mL
5 mM	0.43 mL	2.14 mL	4.27 mL

*The above data is based on the productmolecular weight 468.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.