IOX1

Catalog No. A14277

IOX1是2OG加氧酶（包括JmjC脱甲基酶）的有效且广谱抑制剂。

Technical details

Catalog Num	A14277
M. Wt	189.17
Formula	C10H7NO3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	5852-78-8
Synonyms	IOX 1, Iox-1
SMILES	C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O

Biological Activity

IOX1是2OG加氧酶（包括JmjC脱甲基酶）的有效且广谱抑制剂。

Targets

Target	Value
KDM3A	IC50: 0.1μM
KDM4C	IC50: 0.6μM
KDM6B	IC50: 1.6μM
KDM2A	IC50: 1.8μM
KDM4E	IC50: 2.3μM
KDM5C	IC50: 19μM
PHD2	IC50: 33μM

Solubility *

In vitro	DMSO	36 mg/mL (190.3 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	52.86 mL	264.31 mL	528.63 mL
0.5 mM	10.57 mL	52.86 mL	105.73 mL
1 mM	5.29 mL	26.43 mL	52.86 mL
5 mM	1.06 mL	5.29 mL	10.57 mL

*The above data is based on the productmolecular weight 189.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.