PTC-209 HBr

Catalog No. A14280

PTC-209 HBr是PTC-209的氢溴酸盐。PTC-209是一种有效的选择性BMI-1抑制剂，在HEK293T细胞系中的IC50为0.5μM，可导致癌症起始细胞（CIC）不可逆地减少。

Technical details

Catalog Num	A14280
M. Wt	576.1
Formula	C17H13Br2N5OS.HBr
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1217022-63-3
Synonyms	PTX209
SMILES	CC1=C(N2C=CC=NC2=N1)C3=CSC(=N3)NC4=C(C=C(C=C4Br)OC)Br.Br

Biological Activity

PTC-209 HBr是PTC-209的氢溴酸盐。PTC-209是一种有效的选择性BMI-1抑制剂，在HEK293T细胞系中的IC50为0.5μM，可导致癌症起始细胞（CIC）不可逆地减少。

Targets

BMI-1
0.5 μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 99 mg/mL (171.84 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+35% PEG 300+2% Tween 80+ddH2O	6 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.36 mL	86.79 mL	173.58 mL
0.5 mM	3.47 mL	17.36 mL	34.72 mL
1 mM	1.74 mL	8.68 mL	17.36 mL
5 mM	0.35 mL	1.74 mL	3.47 mL

*The above data is based on the productmolecular weight 576.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.