ISRIB
Catalog No. A14302
ISRIB是一种有效的选择性PERK抑制剂,IC50为5 nM。
- Satoshi Watanabe, .et al. Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis, Proc Natl Acad Sci U S A, 2021, May 18;118(20) PMID: 33972447
- Satoshi Watanabe, .et al. Resetting proteostasis with ISRIB prevents pulmonary fibrosis, bioRxiv, 2020, February 27
Catalog Num | A14302 |
---|---|
M. Wt | 451.34 |
Formula | C22H24Cl2N2O4 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1597403-47-8 |
Synonyms | |
SMILES | C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl |
ISRIB是一种有效的选择性PERK抑制剂,IC50为5 nM。
Targets
PERK | ||||
5 nM |
In vitro | DMSO | 4 mg/mL (8.86 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.16 mL | 110.78 mL | 221.56 mL |
0.5 mM | 4.43 mL | 22.16 mL | 44.31 mL |
1 mM | 2.22 mL | 11.08 mL | 22.16 mL |
5 mM | 0.44 mL | 2.22 mL | 4.43 mL |
*The above data is based on the productmolecular weight 451.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.