Gilteritinib (ASP2215)

Catalog No. A14411

Gilteritinib (ASP2215)是一种有效的FLT3/AXL抑制剂，对具有AML突变或FLT3-ITD和FLT3-D835的AML具有有效的抗白血病活性。

Product Citations

Mohammad Azhar, .et al. Rational polypharmacological targeting of FLT3, JAK2, ABL, and ERK1 suppresses the adaptive resistance to FLT3 inhibitors in AML, Blood Adv, 2022, Aug 31 PMID: 36044389

Technical details

Catalog Num	A14411
M. Wt	552.71
Formula	C29H44N8O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1254053-43-4
Synonyms	ASP2215, ASP-2215, ASP 2215
SMILES	CCC1=NC(=C(N=C1NC2CCOCC2)NC3=CC(=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC)C(=O)N

Biological Activity

Gilteritinib (ASP2215)是一种有效的FLT3/AXL抑制剂，对具有AML突变或FLT3-ITD和FLT3-D835的AML具有有效的抗白血病活性。

Solubility *

In vitro	DMSO	90 mg/mL (162.83 mM)
	Water	Insoluble
	Ethanol	77 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.09 mL	90.46 mL	180.93 mL
0.5 mM	3.62 mL	18.09 mL	36.19 mL
1 mM	1.81 mL	9.05 mL	18.09 mL
5 mM	0.36 mL	1.81 mL	3.62 mL

*The above data is based on the productmolecular weight 552.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.