Afatinib dimaleate

Catalog No. A14985

Afatinib dimaleate是一种不可逆的EGFR/HER2抑制剂，对于HER2的体外药效IC50为14 nM。

Technical details

Catalog Num	A14985
M. Wt	718.08
Formula	C32H33ClFN5O11
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	850140-73-7
Synonyms	BIBW 2992MA2, BIBW-2992, BIBW2992, BIBW 2992, Afatinib
SMILES	CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O

Biological Activity

Afatinib dimaleate是一种不可逆的EGFR/HER2抑制剂，对于HER2的体外药效IC50为14 nM。

Targets

EGFR (L858R)	EGFR (wt)	EGFR (L858R/T790M)	HER2
0.4 nM	0.5 nM	10 nM	14 nM

Solubility *

In vitro (25°C)	DMSO	87 mg/mL (121.3 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+ddH2O	26 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.93 mL	69.63 mL	139.26 mL
0.5 mM	2.79 mL	13.93 mL	27.85 mL
1 mM	1.39 mL	6.96 mL	13.93 mL
5 mM	0.28 mL	1.39 mL	2.79 mL

*The above data is based on the productmolecular weight 718.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.