Guanfacine hydrochloride

Catalog No. A15098

Guanfacine hydrochloride是一种抗高血压药，是一种选择性的α2A肾上腺素受体激动剂，Kd为31 nM，选择性是α2B肾上腺素受体的60倍。

Technical details

Catalog Num	A15098
M. Wt	282.55
Formula	C9H10Cl3N3O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	29110-48-3
Synonyms	Guanfacine, Tenex, Intuniv
SMILES	C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl

Biological Activity

Guanfacine hydrochloride是一种抗高血压药，是一种选择性的α2A肾上腺素受体激动剂，Kd为31 nM，选择性是α2B肾上腺素受体的60倍。

Targets

α2A-adrenoceptor

Solubility *

In vitro	DMSO	48 mg/mL (169.88 mM)
	Water	26 mg/mL (92.01 mM)
	Ethanol	48 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.39 mL	176.96 mL	353.92 mL
0.5 mM	7.08 mL	35.39 mL	70.78 mL
1 mM	3.54 mL	17.7 mL	35.39 mL
5 mM	0.71 mL	3.54 mL	7.08 mL

*The above data is based on the productmolecular weight 282.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.