Desvenlafaxine succinate hydrate

Catalog No. A15491

Desvenlafaxine succinate hydrate是一种新型5-羟色胺(5-HT)转运蛋白和去甲肾上腺素(NE)转运蛋白重吸收抑制剂，Ki值分别为40.2 nM和558.4 nM

Technical details

Catalog Num	A15491
M. Wt	399.48
Formula	C20H33NO7
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	386750-22-7
Synonyms	Pristiq succinate hydrate, O-Desmethylvenlafaxine succinate hydrate
SMILES	CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O.C(CC(=O)O)C(=O)O.O

Biological Activity

Desvenlafaxine succinate hydrate是一种新型5-羟色胺(5-HT)转运蛋白和去甲肾上腺素(NE)转运蛋白重吸收抑制剂，Ki值分别为40.2 nM和558.4 nM

Targets

5-HT	Norepinephrine (NE)
40.2 nM(Ki)	558.4 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	76 mg/mL (181.66 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% methylcellulose+0.2% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.03 mL	125.16 mL	250.33 mL
0.5 mM	5.01 mL	25.03 mL	50.07 mL
1 mM	2.5 mL	12.52 mL	25.03 mL
5 mM	0.5 mL	2.5 mL	5.01 mL

*The above data is based on the productmolecular weight 399.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.