FG-2216

Catalog No. A15530

FG-2216是一种有效的HIF-脯氨酰羟化酶抑制剂，对PDH2酶的IC50为3.9 uM；生物利用度并在体内诱导显着且可逆的Epo诱导。

Technical details

Catalog Num	A15530
M. Wt	280.66
Formula	C12H9ClN2O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	223387-75-5
Synonyms	YM-311
SMILES	C1=CC=C2C(=C1)C(=C(N=C2Cl)C(=O)NCC(=O)O)O

Biological Activity

FG-2216是一种有效的HIF-脯氨酰羟化酶抑制剂，对PDH2酶的IC50为3.9 uM；生物利用度并在体内诱导显着且可逆的Epo诱导。

Targets

PHD2
3.9 μM

Solubility *

In vitro (25°C)	DMSO	48 mg/mL (171.02 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+40% PEG 300+2% Twenn 80+ddH2O	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.63 mL	178.15 mL	356.3 mL
0.5 mM	7.13 mL	35.63 mL	71.26 mL
1 mM	3.56 mL	17.82 mL	35.63 mL
5 mM	0.71 mL	3.56 mL	7.13 mL

*The above data is based on the productmolecular weight 280.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.