Selonsertib

Catalog No. A15991

Selonsertib是一种凋亡信号调节激酶1（ASK1）的口服生物利用抑制剂，具有潜在的抗炎，抗肿瘤和抗纤维化活性。

Product Citations

Lisa M Kim, .et al. Sustained Oncogenic Signaling in the Cytostatic State Enables Targeting of Nonproliferating Persistent Cancer Cells, Cancer Res, 2022, Sep 2;82(17):3045-3057 PMID: 35792658
Luwa Yuan, .et al. 14-3-3 signal adaptor and scaffold proteins mediate GPCR trafficking, Sci Rep, 2019, 9:11156 PMID: 31371790

Technical details

Catalog Num	A15991
M. Wt	445.5
Formula	C24H24FN7O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1448428-04-3
Synonyms	GS-4997, GS4997, GS 4997
SMILES	O=C(NC1=NC(C2=NN=CN2C(C)C)=CC=C1)C3=CC(N4C=C(C5CC5)N=C4)=C(C)C=C3F

Biological Activity

Selonsertib是一种凋亡信号调节激酶1（ASK1）的口服生物利用抑制剂，具有潜在的抗炎，抗肿瘤和抗纤维化活性。

Targets

ASK1

Solubility *

In vitro	DMSO	34 mg/mL (76.31 mM)
	Water	Insoluble
	Ethanol	23 mg/mL (51.63 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.45 mL	112.23 mL	224.47 mL
0.5 mM	4.49 mL	22.45 mL	44.89 mL
1 mM	2.24 mL	11.22 mL	22.45 mL
5 mM	0.45 mL	2.24 mL	4.49 mL

*The above data is based on the productmolecular weight 445.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.