NSC87877

Catalog No. A16120

NSC-87877是SHP-1和SHP-2的细胞可渗透抑制剂，IC50值分别为355和318 nM。

Technical details

Catalog Num	A16120
M. Wt	503.42
Formula	C19H13N3O7S2.2Na
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	56932-43-5
Synonyms	NSC-87877, NSC 87877
SMILES	C1=CC2=C(C(=O)C(=NNC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)[O-])C=C2S(=O)(=O)[O-])N=C1.[Na+].[Na+]

Biological Activity

NSC-87877是SHP-1和SHP-2的细胞可渗透抑制剂，IC50值分别为355和318 nM。

Targets

SHP-2	SHP-1
318 nM	355 nM

Solubility *

In vitro (25°C)	DMSO	85 mg/mL (168.84 mM)
	Water	85 mg/mL (168.84 mM)
	Ethanol	Insoluble
In vivo	2% DMSO+35% PEG 300+2% Tween 80+ddH2O	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.86 mL	99.32 mL	198.64 mL
0.5 mM	3.97 mL	19.86 mL	39.73 mL
1 mM	1.99 mL	9.93 mL	19.86 mL
5 mM	0.4 mL	1.99 mL	3.97 mL

*The above data is based on the productmolecular weight 503.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.