SAR245409 (XL765, Voxtalisib)

Catalog No. A16276

SAR245409 (XL765,Voxtalisib)是PI3K/mTOR双激酶抑制剂XL765是口服生物可利用的小分子，靶向PI3K/mTOR信号途径中的磷脂酰肌醇3激酶（PI3K）和雷帕霉素（mTOR）激酶的哺乳动物靶标，具有潜在的抗肿瘤活性。

Technical details

Catalog Num	A16276
M. Wt	270.29
Formula	C13H14N6O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	934493-76-2
Synonyms	Voxtalisib, XL765, SAR 245409, SAR-245409, XL 765, XL-765
SMILES	O=C1C(C2=NNC=C2)=CC3=C(C)N=C(N)N=C3N1CC

Biological Activity

Targets

Target	Value
PI3Kγ	IC50: 9nM
PI3Kα	IC50: 39nM
PI3Kδ	IC50: 43nM
PI3Kβ	IC50: 113nM
DNA-PK	IC50: 150nM
mTOR	IC50: 157nM

Solubility *

In vitro	DMSO	53 mg/mL (196.08 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37 mL	184.99 mL	369.97 mL
0.5 mM	7.4 mL	37 mL	73.99 mL
1 mM	3.7 mL	18.5 mL	37 mL
5 mM	0.74 mL	3.7 mL	7.4 mL

*The above data is based on the productmolecular weight 270.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.