Fluorouracil (Adrucil)

Catalog No. A10042

Fluorouracil (Adrucil)是一种是DNA/RNA合成抑制剂，通过不可逆地抑制胸苷酸合酶起作用。

Product Citations

T Hoshiba ,etc. Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels: Mechanism of 5-fluorouracil resistance in colorectal tumor cells. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2016, 1863(11), 2749-2757.

Technical details

Catalog Num	A10042
M. Wt	130.1
Formula	C4H3FN2O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	51-21-8
Synonyms	Adrucil, 5-FU, Carac, Efudex, Fluoroplex
SMILES	C1=C(C(=O)NC(=O)N1)F

Biological Activity

Fluorouracil (Adrucil)是一种是DNA/RNA合成抑制剂，通过不可逆地抑制胸苷酸合酶起作用。

Targets

Thymidylate synthase (Tumor cells)

Solubility *

In vitro (25°C)	DMSO	22 mg/mL (169.12 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	saline (warming)	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	76.86 mL	384.32 mL	768.64 mL
0.5 mM	15.37 mL	76.86 mL	153.73 mL
1 mM	7.69 mL	38.43 mL	76.86 mL
5 mM	1.54 mL	7.69 mL	15.37 mL

*The above data is based on the productmolecular weight 130.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.