AG14361

Catalog No. A10046

AG14361是一种有效的PARP抑制剂，可在MMR（错配修复）有效/不足的细胞中增强替莫唑胺（TMZ）的细胞毒性。

Product Citations

Vimal Pandey, .et al. Roscovitine effectively enhances antitumor activity of temozolomide in vitro and in vivo mediated by increased autophagy and Caspase-3 dependent apoptosis, Scientific Reports, 2019, 9, Article number: 5012

Technical details

Catalog Num	A10046
M. Wt	320.4
Formula	C19H20N4O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	328543-09-5
Synonyms	AG-14361
SMILES	CN(C)CC1=CC=C(C=C1)C2=NC3=CC=CC4=C3N2CCNC4=O

Biological Activity

AG14361是一种有效的PARP抑制剂，可在MMR（错配修复）有效/不足的细胞中增强替莫唑胺（TMZ）的细胞毒性。

Targets

PARP1 (Cell-free assay)
<5 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	11 mg/mL (34.33 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.21 mL	156.05 mL	312.11 mL
0.5 mM	6.24 mL	31.21 mL	62.42 mL
1 mM	3.12 mL	15.61 mL	31.21 mL
5 mM	0.62 mL	3.12 mL	6.24 mL

*The above data is based on the productmolecular weight 320.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.