Amlodipine besylate (Norvasc)

Catalog No. A10069

Amlodipine besylate是一种L型钙通道阻滞剂，具有降压作用。它抑制去极化大鼠主动脉中Ca2 +诱导的收缩（IC50 = 1.9 nM）。

Technical details

Catalog Num	A10069
M. Wt	567.1
Formula	C20H25ClN2O5.C6H6O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	111470-99-6
Synonyms	Istin, Norvasc
SMILES	CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O

Biological Activity

Amlodipine besylate是一种L型钙通道阻滞剂，具有降压作用。它抑制去极化大鼠主动脉中Ca2 +诱导的收缩（IC50 = 1.9 nM）。

Solubility *

In vitro (25°C)	DMSO	102 mg/mL (179.87 mM)
	Water	Insoluble
	Ethanol	13 mg/mL (22.92 mM)
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.63 mL	88.17 mL	176.34 mL
0.5 mM	3.53 mL	17.63 mL	35.27 mL
1 mM	1.76 mL	8.82 mL	17.63 mL
5 mM	0.35 mL	1.76 mL	3.53 mL

*The above data is based on the productmolecular weight 567.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

Amlodipine besylate (Norvasc)

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions