Artesunate

Catalog No. A10087

Artesunate是用于治疗疟疾的青蒿素的半合成衍生物。它也被证明可以有效对抗其他寄生虫，例如肝吸虫。青蒿琥酯还显示出针对不同肿瘤类型的癌细胞系的细胞毒性作用。青蒿琥酯已显示出通过抑制类风湿关节炎成纤维细胞样滑膜细胞中的NF-B和PI3激酶/ Akt信号通路来抑制TNF诱导的促炎细胞因子的产生。

Technical details

Catalog Num	A10087
M. Wt	384.4
Formula	C19H28O8
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	88495-63-0
Synonyms
SMILES	C[C@@H]1CC[C@H]2[C@H]([C@@H](O[C@H]3[C@@]24[C@H]1CCC(O3)(OO4)C)OC(=O)CCC(=O)O)C

Biological Activity

Targets

EXP1(a membrane glutathione S-transferase)

Solubility *

In vitro	DMSO	69 mg/mL (179.49 mM)
	Water	Insoluble
	Ethanol	69 mg/mL (179.49 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.01 mL	130.07 mL	260.15 mL
0.5 mM	5.2 mL	26.01 mL	52.03 mL
1 mM	2.6 mL	13.01 mL	26.01 mL
5 mM	0.52 mL	2.6 mL	5.2 mL

*The above data is based on the productmolecular weight 384.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.