AT7519

Catalog No. A10093

AT7519是多种细胞周期蛋白依赖性激酶（CDK）的抑制剂，可导致细胞周期停滞，诱导细胞凋亡和抑制肿瘤细胞增殖。作用于CDK1，2，4，6和9时，IC50为10-210 nM，对CDK3作用效果稍弱，对CDK7几乎没有抑制活性。

Technical details

Catalog Num	A10093
M. Wt	382.2
Formula	C16H17Cl2N5O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	844442-38-2
Synonyms	AT-7519
SMILES	C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl

Biological Activity

Targets

Target	Value
CDK9/CyclinT	IC50: <10nM
CDK5/p35	IC50: 13nM
CDK2/CyclinA	IC50: 47nM
GSK-3β	IC50: 89nM
CDK4/CyclinD1	IC50: 100nM
CDK6/CyclinD3	IC50: 170nM
CDK1/CyclinB	IC50: 210nM
CDK3/CyclinE	IC50: 360nM
PI3Kβ	IC50: >1μM
PLK3	IC50: >1μM
RET	IC50: >1μM
SGK	IC50: >1μM
TrkB	IC50: >1μM
JAK2	IC50: >1μM
CDK7/CyclinH/MAT1	IC50: 2.4μM
SAPK2A(p38α)	IC50: >10μM
p70S6K	IC50: >10μM
PDGFR	IC50: >10μM
PDK-1	IC50: >10μM
PKBβ	IC50: >10μM
VEGFR1	IC50: >10μM
AuroraA	IC50: >10μM
c-Abl	IC50: >10μM
c-Src	IC50: >10μM
Chk1	IC50: >10μM
EGFR	IC50: >10μM
FGFR3	IC50: >10μM
IR	IC50: >10μM
JNK2	IC50: >10μM
MAPK1	IC50: >10μM
MEK1	IC50: >10μM
Met	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	9 mg/mL (23.54 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.16 mL	130.82 mL	261.64 mL
0.5 mM	5.23 mL	26.16 mL	52.33 mL
1 mM	2.62 mL	13.08 mL	26.16 mL
5 mM	0.52 mL	2.62 mL	5.23 mL

*The above data is based on the productmolecular weight 382.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.