AZD8055

Catalog No. A10114

AZD8055是一种有效的，选择性的ATP竞争性mTOR激酶抑制剂，IC50为0.8 nM。

Product Citations

L. M. C. Koene, .et al. Effects of antiepileptic drugs in a new TSC/mTOR-dependent epilepsy mouse model, ACTN, 2019, June PMID: 31353861
Helga Weber, .et al. Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice, Oncotarget, 2015, Oct 13; 6(31): 31877–31888 PMID: 26397134
Kentaro Hirose, .et al. Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins, BMC Dev Biol, 2014, 14: 42. PMID: 25480380

Technical details

Catalog Num	A10114
M. Wt	465.5
Formula	C25H31N5O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1009298-09-2
Synonyms	AZD-8055
SMILES	C[C@H]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOC[C@@H]5C

Biological Activity

AZD8055是一种有效的，选择性的ATP竞争性mTOR激酶抑制剂，IC50为0.8 nM。

Targets

Target	Value
mTOR(truncated)	IC50: 0.13nM
mTOR(fulllength)	IC50: 0.8nM
DNA-PK	IC50: 1370nM
PI3Kδ	IC50: 3200nM
PI3Kα	IC50: 3590nM
ATM	IC50: 7350nM
PI3Kγ	IC50: >14790nM
PI3Kβ	IC50: 18900nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 49 mg/mL (105.25 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (6.44 mM)
In vivo	4% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.48 mL	107.41 mL	214.82 mL
0.5 mM	4.3 mL	21.48 mL	42.96 mL
1 mM	2.15 mL	10.74 mL	21.48 mL
5 mM	0.43 mL	2.15 mL	4.3 mL

*The above data is based on the productmolecular weight 465.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.