AZD8931 (Sapitinib)

Catalog No. A10116

AZD8931 (Sapitinib)是ErbB1，ErbB2和ErbB3受体信号传导的等效抑制剂。

Product Citations

Takeshi Ito, .et al. Mathematical analysis of gefitinib resistance of lung adenocarcinoma caused by MET amplification, Biochem Biophys Res Commun, 2019, in Press

Technical details

Catalog Num	A10116
M. Wt	473.9
Formula	C23H25ClFN5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	848942-61-0
Synonyms	AZD-8931, Momelotinib, Sapitinib
SMILES	CNC(=O)CN1CCC(CC1)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC

Biological Activity

AZD8931 (Sapitinib)是ErbB1，ErbB2和ErbB3受体信号传导的等效抑制剂。

Targets

ErbB2 (Cell-free assay)	EGFR (Cell-free assay)	ErbB3 (Cell-free assay)
3 nM	4 nM	4 nM

Solubility *

In vitro (25°C)	DMSO	37 mg/mL (78.07 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.1 mL	105.51 mL	211.01 mL
0.5 mM	4.22 mL	21.1 mL	42.2 mL
1 mM	2.11 mL	10.55 mL	21.1 mL
5 mM	0.42 mL	2.11 mL	4.22 mL

*The above data is based on the productmolecular weight 473.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.