Belinostat (PXD101)

Catalog No. A10122

Belinostat（PXD101）是一种HDAC抑制剂，可抑制HeLa细胞提取物中的HDAC活性，IC50为27 nM。

Product Citations

Shariful Islam, .et al. Resistance to histone deacetylase inhibitors confers hypersensitivity to oncolytic reovirus therapy, Blood Adv, 2020, 4(20): 5297-5310 PMID: 33108458

Technical details

Catalog Num	A10122
M. Wt	318.4
Formula	C15H14N2O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	414864-00-9
Synonyms	PX105684
SMILES	C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)/C=C/C(=O)NO

Biological Activity

Belinostat（PXD101）是一种HDAC抑制剂，可抑制HeLa细胞提取物中的HDAC活性，IC50为27 nM。

Targets

HDAC (Cell-free assay)
27 nM

Solubility *

In vitro (25°C)	DMSO	56 mg/mL (175.9 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.41 mL	157.04 mL	314.07 mL
0.5 mM	6.28 mL	31.41 mL	62.81 mL
1 mM	3.14 mL	15.7 mL	31.41 mL
5 mM	0.63 mL	3.14 mL	6.28 mL

*The above data is based on the productmolecular weight 318.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.