Berberine HCl

Catalog No. A10126

Berberine hydrochloride被发现具有对心血管系统的多种有益作用和显着的抗炎活性。小ber碱可有效降低LPS刺激的巨噬细胞的细胞内超氧化物水平。小碱对细胞氧化还原的这种恢复是通过其对gp91phox表达的选择性抑制和SOD活性的增强而介导的。

Product Citations

Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347

Technical details

Catalog Num	A10126
M. Wt	371.8
Formula	C20H18ClNO4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	633-65-8
Synonyms
SMILES	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]

Biological Activity

Targets

Solubility *

In vitro (25°C)	DMSO	35 mg/mL (94.13 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+ddH2O	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.9 mL	134.48 mL	268.96 mL
0.5 mM	5.38 mL	26.9 mL	53.79 mL
1 mM	2.69 mL	13.45 mL	26.9 mL
5 mM	0.54 mL	2.69 mL	5.38 mL

*The above data is based on the productmolecular weight 371.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.