Biochanin A (4-Methylgenistein)

Catalog No. A10146

Biochanin A (4-Methylgenistein)是一种抗增殖和抗炎剂，可抑制iNOS的表达和脂多糖（LPS）诱导的巨噬细胞中一氧化氮的产生。此外，Biochanin A还具有阻断IκBα和p38 MAPK磷酸化的能力，从而阻止了NF-κB的活化。此外，已观察到生物chanin A抑制IL-6，IL-1β和TNF-α的产生。

Technical details

Catalog Num	A10146
M. Wt	284.3
Formula	C16H12O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	491-80-5
Synonyms	4-Methylgenistein
SMILES	COC1=CC=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)O)O

Biological Activity

Targets

FAAH (rat)	FAAH (mouse)	FAAH (human)	EGFR
1.4 μM	1.8 μM	2.4 μM	91.5 μM

Solubility *

In vitro	DMSO	51 mg/mL (179.41 mM)
	Water	Insoluble
	Ethanol	8 mg/mL (28.14 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.17 mL	175.87 mL	351.74 mL
0.5 mM	7.03 mL	35.17 mL	70.35 mL
1 mM	3.52 mL	17.59 mL	35.17 mL
5 mM	0.7 mL	3.52 mL	7.03 mL

*The above data is based on the productmolecular weight 284.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.