PD184352 (CI-1040)

Catalog No. A10212

PD184352 (CI-1040)是一种ATP非竞争性MEK1/2抑制剂，在基于细胞的测定中，IC50为17 nM，对MEK1/2的选择性是对MEK5的100倍。

Product Citations

Sachio Suzuki, .et al. A chemogenetic platform for controlling plasma membrane signaling and synthetic signal oscillation, Cell Chem Biol, 2022, Sep 15;29(9):1446-1464 PMID: 35835118
Masaru Yoshikawa, .et al. Synthetic Protein Condensates That Inducibly Recruit and Release Protein Activity in Living Cells, J Am Chem Soc, 2021, May 5;143(17):6434-6446 PMID: 33890764

Technical details

Catalog Num	A10212
M. Wt	478.7
Formula	C17H14ClF2IN2O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	212631-79-3
Synonyms	CI-1040
SMILES	C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl

Biological Activity

PD184352 (CI-1040)是一种ATP非竞争性MEK1/2抑制剂，在基于细胞的测定中，IC50为17 nM，对MEK1/2的选择性是对MEK5的100倍。

Targets

MEK1 (Cell-free assay)	MEK2 (Cell-free assay)
17 nM	17 nM

Solubility *

In vitro (25°C)	DMSO	92 mg/mL (192.19 mM)
	Water	Insoluble
	Ethanol	13 mg/mL (27.15 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol, pH 9	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.89 mL	104.45 mL	208.9 mL
0.5 mM	4.18 mL	20.89 mL	41.78 mL
1 mM	2.09 mL	10.44 mL	20.89 mL
5 mM	0.42 mL	2.09 mL	4.18 mL

*The above data is based on the productmolecular weight 478.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.