Clozapine

Catalog No. A10236

Clozapine是一种有效的5-HT1C受体拮抗剂，作用于5-HT刺激的磷酸肌醇水解。

Product Citations

Madeleine S A Tan, .et al. Fabrication and Characterization of Clozapine Nanoemulsion Sol-Gel for Intranasal Administration, Mol Pharm, 2022, Sep 23 PMID: 36149013
Madeleine S. A. Tan, .et al. Clozapine-Encapsulated Binary Mixed Micelles in Thermosensitive Sol-Gels for Intranasal Administration, Gels, 2022, Jan; 8(1): 38 PMID: 35049572
Milan D Valyear, .et al. Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts, Nat Commun, 2020, Jul 28;11(1):3764 PMID: 32724058
Yutaro Kobayashi, .et al. Clozapine-dependent inhibition of EGF/neuregulin receptor (ErbB) kinases, Transl Psychiatry, 2019, 9:181 PMID: 31371697
M.D. Valyear, .et al. Divergent mesolimbic dopamine circuits support alcohol-seeking triggered by discrete cues and contexts, bioRxiv, 2018, 2018

Technical details

Catalog Num	A10236
M. Wt	326.8
Formula	C18H19ClN4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	5786-21-0
Synonyms	Clozaril, Fazaclo, HF 1854, Iprox, Klozapol, Leponex
SMILES	CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

Biological Activity

Clozapine是一种有效的5-HT1C受体拮抗剂，作用于5-HT刺激的磷酸肌醇水解。

Targets

5-HT2

Solubility *

In vitro	DMSO	59 mg/mL (180.52 mM)
	Water	Insoluble
	Ethanol	29 mg/mL (88.73 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.6 mL	153 mL	306 mL
0.5 mM	6.12 mL	30.6 mL	61.2 mL
1 mM	3.06 mL	15.3 mL	30.6 mL
5 mM	0.61 mL	3.06 mL	6.12 mL

*The above data is based on the productmolecular weight 326.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.