Costunolide

Catalog No. A10240

Costunolide是人类端粒酶活性的抑制剂（MCF-7乳腺癌细胞中IC50 = 65μM）。

Technical details

Catalog Num	A10240
M. Wt	232.3
Formula	C15H20O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	553-21-9
Synonyms
SMILES	CC1=CCC/C(=C/[C@@H]2[C@@H](CC1)C(=C)C(=O)O2)/C

Biological Activity

Costunolide是人类端粒酶活性的抑制剂（MCF-7乳腺癌细胞中IC50 = 65μM）。

Targets

FPTase	Telomerase (MDA-MB-231)	Telomerase (MCF-7)
20 μM	65 μM	90 μM

Solubility *

In vitro (25°C)	DMSO	43 mg/mL (185.08 mM)
	Water	Insoluble
	Ethanol	1 mg/mL (4.3 mM)
In vivo	2% DMSO+corn oil	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	43.05 mL	215.24 mL	430.48 mL
0.5 mM	8.61 mL	43.05 mL	86.1 mL
1 mM	4.3 mL	21.52 mL	43.05 mL
5 mM	0.86 mL	4.3 mL	8.61 mL

*The above data is based on the productmolecular weight 232.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.