CUDC-101

Catalog No. A10246

CUDC-101是一种抑制多种靶标的新型化合物，旨在抑制HDAC，EGFR和Her2。

Technical details

Catalog Num	A10246
M. Wt	434.5
Formula	C24H26N4O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1012054-59-9
Synonyms	CUDC101
SMILES	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO

Biological Activity

CUDC-101是一种抑制多种靶标的新型化合物，旨在抑制HDAC，EGFR和Her2。

Targets

Target	Value
EGFR	IC50: 2.4nM
HDAC	IC50: 4.4nM
HDAC1	IC50: 4.5nM
HDAC6	IC50: 5.1nM
HDAC3	IC50: 9.1nM
HDAC5	IC50: 11.4nM
HDAC2	IC50: 12.6nM
HDAC4	IC50: 13.2nM
HER2	IC50: 15.7nM
HDAC10	IC50: 26.1nM
HDAC9	IC50: 67.2nM
HDAC8	IC50: 79.8nM
HDAC7	IC50: 373nM

Solubility *

In vitro (25°C)	DMSO	20 mg/mL (46.03 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	15% Captisol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.01 mL	115.07 mL	230.15 mL
0.5 mM	4.6 mL	23.01 mL	46.03 mL
1 mM	2.3 mL	11.51 mL	23.01 mL
5 mM	0.46 mL	2.3 mL	4.6 mL

*The above data is based on the productmolecular weight 434.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.