Cyclosporin A

Catalog No. A10260

Cyclosporin A (Cyclosporine A)是一种免疫抑制剂，广泛用于异体后器官移植，以降低免疫系统的活性。

Product Citations

X Jia, .et al. Arsenic Induces Hepatic Insulin Resistance via mtROS-NLRP3 Inflammasome Pathway, J Hazard Mater, 2020, Jun 4;399:123034 PMID: 32544768
Y Huang, .et al. STIM1 controls calcineurin/Akt/mTOR/NFATC2?mediated osteoclastogenesis induced by RANKL/M?CSF, Experimental and Therapeutic Medicine, 2020, 20(2), 736-747
Miyayama Y, .et al. Comparative study on the replication of HCV1b genome between wild type and cell culture adaptive mutant in regard to sensitivities against anti-HCV drugs, Microbiol Immunol, 2019, Dec 19 PMID: 31854467

Technical details

Catalog Num	A10260
M. Wt	1202.6
Formula	C62H111N11O12
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	59865-13-3
Synonyms	Ciclosporin A, CsA, Ciclosporin, cyclosporine, cyclosporin,
SMILES	CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

Biological Activity

Cyclosporin A (Cyclosporine A)是一种免疫抑制剂，广泛用于异体后器官移植，以降低免疫系统的活性。

Targets

calcineurin (Cell-free assay)
7 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 99 mg/mL (82.32 mM)
	Water	Insoluble
	Ethanol	Warmed: 99 mg/mL (82.32 mM)
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	8.32 mL	41.58 mL	83.15 mL
0.5 mM	1.66 mL	8.32 mL	16.63 mL
1 mM	0.83 mL	4.16 mL	8.32 mL
5 mM	0.17 mL	0.83 mL	1.66 mL

*The above data is based on the productmolecular weight 1202.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.