Cyt387 (Momelotinib)

Catalog No. A10263

Cyt387 (Momelotinib)是Janus激酶JAK1和JAK2的抑制剂，可作为ATP竞争者，IC50值分别为11和18 nM。

Product Citations

Alex Bainbridge, .et al. IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway, Nucleic Acids Research, 2020, April

Technical details

Catalog Num	A10263
M. Wt	414.5
Formula	C23H22N6O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1056634-68-4
Synonyms	CYT 11387, Cyt-387
SMILES	C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N

Biological Activity

Cyt387 (Momelotinib)是Janus激酶JAK1和JAK2的抑制剂，可作为ATP竞争者，IC50值分别为11和18 nM。

Targets

JAK1	JAK2	JAK3
11 nM	18 nM	155 nM

Solubility *

In vitro (25°C)	DMSO	67 mg/mL (161.65 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+40%PEG 300+ 3% Tween80 + ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.13 mL	120.63 mL	241.25 mL
0.5 mM	4.83 mL	24.13 mL	48.25 mL
1 mM	2.41 mL	12.06 mL	24.13 mL
5 mM	0.48 mL	2.41 mL	4.83 mL

*The above data is based on the productmolecular weight 414.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.