CYT997 (Lexibulin)

Catalog No. A10264

CYT997 (Lexibulin)是一种新型的抗癌血管分裂剂(VDA)。在体外，CYT997被证明可有效抑制血管内皮生长因子刺激的人脐静脉内皮细胞（IC（50）3.7±1.8 nM）的增殖，并在100 nM时引起明显的形态变化，包括膜起泡。

Technical details

Catalog Num	A10264
M. Wt	434.5
Formula	C24H30N6O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	917111-44-5
Synonyms	CYT-997, Lexibulin
SMILES	CCC[C@@H](C1=CN=CC=C1)NC2=NC(=NC=C2C)C3=CC(=C(C=C3)NC(=O)NCC)OC

Biological Activity

Targets

Microtubules (cancer cell lines)
10 nM-100 nM

Solubility *

In vitro	DMSO	77 mg/mL (177.2 mM)
	Water	Insoluble
	Ethanol	18 mg/mL (41.42 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.01 mL	115.07 mL	230.15 mL
0.5 mM	4.6 mL	23.01 mL	46.03 mL
1 mM	2.3 mL	11.51 mL	23.01 mL
5 mM	0.46 mL	2.3 mL	4.6 mL

*The above data is based on the productmolecular weight 434.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.