Decitabine

Catalog No. A10292

Decitabine是一种次甲基化剂，它通过抑制DNA甲基转移酶来使DNA次甲基化。

Product Citations

Borbala Szabo, .et al. Aspirin mediates its antitumoral effect through inhibiting PTTG1 in pituitary adenoma, J Clin Endocrinol Metab, 2022, Sep 5;dgac496 PMID: 36059148
Sangni Qian, .et al. Hypermethylation of tumor suppressor lncRNA MEF2C-AS1 frequently happened in patients at all stages of colorectal carcinogenesis, Clin Epigenetics, 2022, Sep 5;14(1):111 PMID: 36064442
Borb??la Szab??, .et al. Demethylation status of somatic DNA extracted from pituitary neuroendocrine tumors indicates proliferative behavior, J Clin Endocrinol Metab, 2020, Jun 1;105(6):dgaa156 PMID: 32232382
Bracha Shraibman, .et al. Human Leukocyte Antigen (HLA) Peptides Derived from Tumor Antigens Induced by Inhibition of DNA Methylation for Development of Drug-facilitated Immunotherapy, Mol Cell Proteomics, 2016, Sep; 15(9): 3058-3070 PMID: 27412690

Technical details

Catalog Num	A10292
M. Wt	228.2
Formula	C8H12N4O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	2353-33-5
Synonyms	Dacogen
SMILES	C1[C@@H]([C@H](O[C@H]1N2C=NC(=NC2=O)N)CO)O

Biological Activity

Decitabine是一种次甲基化剂，它通过抑制DNA甲基转移酶来使DNA次甲基化。

Targets

DNA methylation (HL-60, KG1a cells)

Solubility *

In vitro (25°C)	DMSO	44 mg/mL (192.8 mM)
	Water	10 mg/mL (43.81 mM)
	Ethanol	Insoluble
In vivo	water	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	43.82 mL	219.11 mL	438.21 mL
0.5 mM	8.76 mL	43.82 mL	87.64 mL
1 mM	4.38 mL	21.91 mL	43.82 mL
5 mM	0.88 mL	4.38 mL	8.76 mL

*The above data is based on the productmolecular weight 228.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.