DMXAA (ASA404, Vadimezan)

Catalog No. A10324

DMXAA (ASA404,Vadimezan)是一种肿瘤血管破坏剂（tumor-VDA），也是一种DT-diaphorase的竞争性抑制剂。

Product Citations

Zhang X, .et al. Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist, ACS Infect Dis, 2019, May 14 PMID: 31060350
Bowei Liu, .et al. A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists, Antiviral Res, 2017, Nov; 147: 37-46 PMID: 28982551
Fang Guo, .et al. Activation of Stimulator of Interferon Genes in Hepatocytes Suppresses the Replication of Hepatitis B Virus, Antimicrob Agents Chemother, 2017, Oct; 61(10): e00771-17 PMID: 28717041

Technical details

Catalog Num	A10324
M. Wt	282.3
Formula	C17H14O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	117570-53-3
Synonyms	AS-1404, 5,6-MeXAA, NSC-640488, Vadimezan
SMILES	CC1=C(C2=C(C=C1)C(=O)C3=C(O2)C(=CC=C3)CC(=O)O)C

Biological Activity

DMXAA (ASA404,Vadimezan)是一种肿瘤血管破坏剂（tumor-VDA），也是一种DT-diaphorase的竞争性抑制剂。

Targets

DT-diaphorase (Cell-free assay)	DT-diaphorase (Cell-free assay)
20 μM(Ki)	20 μM(Ki)

Solubility *

In vitro	DMSO	7 mg/mL (24.79 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.42 mL	177.12 mL	354.23 mL
0.5 mM	7.08 mL	35.42 mL	70.85 mL
1 mM	3.54 mL	17.71 mL	35.42 mL
5 mM	0.71 mL	3.54 mL	7.08 mL

*The above data is based on the productmolecular weight 282.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.