Dutasteride (Avodart)

Catalog No. A10338

Dutasteride (Avodart)是双重的5-a还原酶抑制剂，可抑制睾丸激素转化为二氢睾丸激素（DHT）。

Product Citations

Makoto Ishikawa, .et al. Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model, Sci Rep, 2018, 8: 12851 PMID: 30150786
Makoto Ishikawa, .et al. TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model, Neuropharmacology, 2016, Dec; 111: 142-159 PMID: 27596950
Makoto Ishikawa, .et al. Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model, Invest Ophthalmol Vis Sci., 2014, 55(12): 8531-8541 PMID: 25406290

Technical details

Catalog Num	A10338
M. Wt	528.5
Formula	C27H30F6N2O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	164656-23-9
Synonyms	Avodart
SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CC[C@@H]5[C@@]3(C=CC(=O)N5)C

Biological Activity

Dutasteride (Avodart)是双重的5-a还原酶抑制剂，可抑制睾丸激素转化为二氢睾丸激素（DHT）。

Targets

5-α reductase

Solubility *

In vitro (25°C)	DMSO	57 mg/mL (107.84 mM)
	Water	Insoluble
	Ethanol	6 mg/mL (11.35 mM)
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.92 mL	94.61 mL	189.21 mL
0.5 mM	3.78 mL	18.92 mL	37.84 mL
1 mM	1.89 mL	9.46 mL	18.92 mL
5 mM	0.38 mL	1.89 mL	3.78 mL

*The above data is based on the productmolecular weight 528.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.