ENMD-2076

Catalog No. A10352

ENMD-2076具有针对Aurora A和Flt3的选择性活性，IC50为14 nM和1.86 nM，对Aurora A的选择性是Aurora B的25倍，对VEGFR2/KDR和VEGFR3，FGFR1和FGFR2和PDGFRα的作用较小。阶段2。

Technical details

Catalog Num	A10352
M. Wt	375.5
Formula	C21H25N7
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	934353-76-1, 1291074-87-7
Synonyms	ENMD2076, ENMD 2076
SMILES	CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)/C=C/C4=CC=CC=C4

Biological Activity

Targets

Target	Value
FLT3	IC50: 1.86nM
RET	IC50: 10.4nM
AuroraA	IC50: 14nM
VEGFR3/FLT4	IC50: 15.9nM
Src	IC50: 20.2nM
NTRK1/TRKA	IC50: 24.2nM
CSF-1R/c-Fms	IC50: 24.8nM
LCK	IC50: 43.7nM
FAK	IC50: 54.9nM
PDGFRα	IC50: 56.4nM
VEGFR2/KDR	IC50: 58.2nM
BLK	IC50: 69.4nM
FGFR2	IC50: 70.8nM
YES1	IC50: 78.4nM
Abl1(T315I)	IC50: 81.3nM
FGFR1	IC50: 92.7nM
Fyn	IC50: 112nM
JAK2	IC50: 120nM
Kit	IC50: 120nM
AuroraB	IC50: 350nM

Solubility *

In vitro (25°C)	DMSO	101 mg/mL (268.99 mM)
	Water	1 mg/mL (2.66 mM)
	Ethanol	Insoluble
In vivo	0.5% CMC+0.25% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.63 mL	133.16 mL	266.31 mL
0.5 mM	5.33 mL	26.63 mL	53.26 mL
1 mM	2.66 mL	13.32 mL	26.63 mL
5 mM	0.53 mL	2.66 mL	5.33 mL

*The above data is based on the productmolecular weight 375.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.