EX 527 (Selisistat)

Catalog No. A10377

EX 527 (Selisistat)是一种有效的选择性SIRT1 III类组蛋白脱乙酰基酶抑制剂，在无细胞分析中的IC50为38 nM。

Product Citations

Takeshi Nakamura, .et al. Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells, Shimane Journal of Medical Science, 2022, 38 (2), 59-66
Bugga Paramesha, .et al. Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function, Antioxidants (Basel), 2021, Feb 24;10(3):338 PMID: 33668369
Wenhui Yao, .et al. Icariin ameliorates endothelial dysfunction in type 1 diabetic rats by suppressing ER stress via the PPARα/Sirt1/AMPKα pathway, J Cell Physiol, 2020, 07 August
Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48
Yoshikawa A, .et al. Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice, J Neurochem, 2015, Feb;132(3):342-53 PMID: 25351847

Technical details

Catalog Num	A10377
M. Wt	248.7
Formula	C13H13ClN2O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	49843-98-3
Synonyms	EX527, EX-527
SMILES	C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N

Biological Activity

EX 527 (Selisistat)是一种有效的选择性SIRT1 III类组蛋白脱乙酰基酶抑制剂，在无细胞分析中的IC50为38 nM。

Targets

SIRT1 (Cell-free assay)
38 nM

Solubility *

In vitro (25°C)	DMSO	46 mg/mL (184.95 mM)
	Water	Insoluble
	Ethanol	17 mg/mL (68.35 mM)
In vivo	5% DMSO+30% PEG 300+ddH2O	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	40.21 mL	201.05 mL	402.09 mL
0.5 mM	8.04 mL	40.21 mL	80.42 mL
1 mM	4.02 mL	20.1 mL	40.21 mL
5 mM	0.8 mL	4.02 mL	8.04 mL

*The above data is based on the productmolecular weight 248.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.