Finasteride

Catalog No. A10387

Finasteride是合成的II型5α-还原酶抑制剂。该酶将睾丸激素转化为二氢睾丸激素(DHT)。

Product Citations

Chen CC, .et al. The Genomic Alterations of 5α-Reductases and Their Inhibitor Finasteride-s Effect in Bladder Cancer, Anticancer Res, 2017, Dec;37(12):6893-6898 PMID: 29187470

Technical details

Catalog Num	A10387
M. Wt	372.5
Formula	C23H36N2O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	98319-26-7
Synonyms	Proscar, Propecia
SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC(C)(C)C)CC[C@@H]4[C@@]3(C=CC(=O)N4)C

Biological Activity

Finasteride是合成的II型5α-还原酶抑制剂。该酶将睾丸激素转化为二氢睾丸激素(DHT)。

Targets

5-α reductase
10.2 nM(Ki)

Solubility *

In vitro	DMSO	67 mg/mL (179.85 mM)
	Water	Insoluble
	Ethanol	67 mg/mL (179.85 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.85 mL	134.23 mL	268.46 mL
0.5 mM	5.37 mL	26.85 mL	53.69 mL
1 mM	2.68 mL	13.42 mL	26.85 mL
5 mM	0.54 mL	2.68 mL	5.37 mL

*The above data is based on the productmolecular weight 372.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.