GDC-0879

Catalog No. A10420

GDC-0879是B-Raf激酶的特异性抑制剂，靶向B-Raf (V600E) (IC50: 0.13 nM)。

Technical details

Catalog Num	A10420
M. Wt	334.4
Formula	C19H18N4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	905281-76-7
Synonyms	GDC0879
SMILES	C1C/C(=N\O)/C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO

Biological Activity

GDC-0879是B-Raf激酶的特异性抑制剂，靶向B-Raf (V600E) (IC50: 0.13 nM)。

Targets

B-Raf (A375, Colo205 cells)
0.13 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 65 mg/mL (194.39 mM)
	Water	Insoluble
	Ethanol	5 mg/mL (14.95 mM)
In vivo	0.5% methylcellulose+0.2% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.9 mL	149.52 mL	299.04 mL
0.5 mM	5.98 mL	29.9 mL	59.81 mL
1 mM	2.99 mL	14.95 mL	29.9 mL
5 mM	0.6 mL	2.99 mL	5.98 mL

*The above data is based on the productmolecular weight 334.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.