GSK1904529A

Catalog No. A10440

GSK1904529A分别用27和25 nmol/L的IC(50)s选择性抑制IGF-IR和IR。

Technical details

Catalog Num	A10440
M. Wt	852
Formula	C44H47F2N9O5S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1089283-49-7
Synonyms	GSK-1904529A
SMILES	CCC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)S(=O)(=O)C)OC)NC4=NC=CC(=N4)C5=C(N=C6N5C=CC=C6)C7=CC(=C(C=C7)OC)C(=O)NC8=C(C=CC=C8F)F

Biological Activity

GSK1904529A分别用27和25 nmol/L的IC(50)s选择性抑制IGF-IR和IR。

Targets

Target	Value
Insulin Receptor	IC50: 25nM
IGF-1R	IC50: 27nM
B-Raf(V600E)	IC50: >2μM
Syk	IC50: 3.2μM
VEGFR2	IC50: 3.2μM
IKK3	IC50: 3.2μM
AuroraB	IC50: 4μM
Fyn	IC50: 6.3μM
RSK1	IC50: 6.3μM
LCK	IC50: 8μM
AuroraA	IC50: >8μM
p38α	IC50: 10μM
PKCε	IC50: 10μM
PKCθ	IC50: >10μM
ActRIIB	IC50: >10μM
Akt1	IC50: >10μM
Akt2	IC50: >10μM
ALK5	IC50: >10μM
CaMKK2	IC50: >10μM
CDK2/CyclinA	IC50: >10μM
EGFR	IC50: >10μM
ErbB2	IC50: >10μM
JNK1	IC50: >10μM
JNK2	IC50: >10μM
JNK3	IC50: >10μM
p70S6K	IC50: >10μM
PAK1	IC50: >10μM
PCTAIRE1	IC50: >10μM
PDK-1	IC50: >10μM
PI3Kα	IC50: >10μM
PI3Kβ	IC50: >10μM
PI3Kδ	IC50: >10μM
PI3Kγ	IC50: >10μM
ROCK1	IC50: >10μM
SIK2	IC50: >10μM
Src1	IC50: >10μM
YAK3	IC50: >10μM
IKK1	IC50: 13μM
IKK2	IC50: 13μM
JAK3	IC50: 13μM
JAK2	IC50: >16μM
ZAP70	IC50: >20μM
ASK1	IC50: >25μM
ErbB4	IC50: >25μM
GSK-3β	IC50: >25μM
ITK	IC50: >25μM
MAPKAPK2	IC50: >25μM

Solubility *

In vitro	DMSO	120 mg/mL (140.85 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	11.74 mL	58.69 mL	117.37 mL
0.5 mM	2.35 mL	11.74 mL	23.47 mL
1 mM	1.17 mL	5.87 mL	11.74 mL
5 mM	0.23 mL	1.17 mL	2.35 mL

*The above data is based on the productmolecular weight 852. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.