Ispinesib (SB-715992)

Catalog No. A10486

Ispinesib (SB-715992)是驱动蛋白纺锤体蛋白的有效抑制剂，驱动蛋白纺锤体蛋白是双极有丝分裂纺锤体形成和有丝分裂细胞周期进程所必需的驱动蛋白。

Technical details

Catalog Num	A10486
M. Wt	517.1
Formula	C30H33ClN4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	336113-53-2
Synonyms	Ispinesib mesylate,B-715992,CK 0238273
SMILES	CC1=CC=C(C=C1)C(=O)N(CCCN)[C@@H](C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4)C(C)C

Biological Activity

Ispinesib (SB-715992)是驱动蛋白纺锤体蛋白的有效抑制剂，驱动蛋白纺锤体蛋白是双极有丝分裂纺锤体形成和有丝分裂细胞周期进程所必需的驱动蛋白。

Targets

KSP (HsEg5) (Cell-free assay)
1.7 nM(Ki app)

Solubility *

In vitro	DMSO	93 mg/mL (179.86 mM)
	Water	Insoluble
	Ethanol	93 mg/mL (179.86 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.34 mL	96.69 mL	193.39 mL
0.5 mM	3.87 mL	19.34 mL	38.68 mL
1 mM	1.93 mL	9.67 mL	19.34 mL
5 mM	0.39 mL	1.93 mL	3.87 mL

*The above data is based on the productmolecular weight 517.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.