ITF2357 (Givinostat)

Catalog No. A10488

ITF2357 (Givinostat)是一种HDACS抑制剂，具有潜在的抗炎、抗血管生成和抗肿瘤活性。

Technical details

Catalog Num	A10488
M. Wt	476.0
Formula	C24H27N3O4.HCl.H2O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	732302-99-7
Synonyms	Gavinostat
SMILES	CC[NH+](CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.O.[Cl-]

Biological Activity

ITF2357 (Givinostat)是一种HDACS抑制剂，具有潜在的抗炎、抗血管生成和抗肿瘤活性。

Targets

HD1-B (Cell-free assay)	HD2 (Cell-free assay)	HD1-A (Cell-free assay)
7.5 nM	10 nM	16 nM

Solubility *

In vitro (25°C)	DMSO	94 mg/mL (197.49 mM)
	Water	Insoluble
	Ethanol	3 mg/mL
In vivo	5%DMSO+40%PEG300++5%Tween80+50%ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.01 mL	105.04 mL	210.08 mL
0.5 mM	4.2 mL	21.01 mL	42.02 mL
1 mM	2.1 mL	10.5 mL	21.01 mL
5 mM	0.42 mL	2.1 mL	4.2 mL

*The above data is based on the productmolecular weight 476.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.