Itraconazole (Sporanox)

Catalog No. A10489

Itraconazole (Sporanox)是CYP3A4相对有效的抑制剂，IC50为6.1nM，用作三唑类抗真菌剂。

Product Citations

Paul Mark Medina, .et al. Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains, Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682

Technical details

Catalog Num	A10489
M. Wt	705.65
Formula	C35H38Cl2N8O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	84625-61-6
Synonyms	Sporanox
SMILES	CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5CO[C@](O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl

Biological Activity

Itraconazole (Sporanox)是CYP3A4相对有效的抑制剂，IC50为6.1nM，用作三唑类抗真菌剂。

Targets

CYP3A4

Solubility *

In vitro (25°C)	DMSO	Warmed: 7 mg/mL (9.91 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40% PEG 300+10% Tween 80+45% ddH2O	1.66 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.17 mL	70.86 mL	141.71 mL
0.5 mM	2.83 mL	14.17 mL	28.34 mL
1 mM	1.42 mL	7.09 mL	14.17 mL
5 mM	0.28 mL	1.42 mL	2.83 mL

*The above data is based on the productmolecular weight 705.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.