LAQ824 (NVP-LAQ824, Dacinostat)

Catalog No. A10516

LAQ824 (NVP-LAQ824)是一种有效的新型组蛋白去乙酰化酶抑制剂，具有显著的抗多发性骨髓瘤活性。

Product Citations

De-Run Chen, .et al. Engineered nanogels simultaneously implement HDAC inhibition and chemotherapy to boost antitumor immunity via pyroptosis, Appl Mater Today, 2022, 26: 101363

Technical details

Catalog Num	A10516
M. Wt	379.5
Formula	C22H25N3O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	404951-53-7
Synonyms	NVP-LAQ824, Dacinostat, LAQ-824
SMILES	C1=CC=C2C(=C1)C(=CN2)CCN(CCO)CC3=CC=C(C=C3)/C=C/C(=O)NO

Biological Activity

LAQ824 (NVP-LAQ824)是一种有效的新型组蛋白去乙酰化酶抑制剂，具有显著的抗多发性骨髓瘤活性。

Targets

HDAC
32 nM

Solubility *

In vitro (25°C)	DMSO	66 mg/mL (173.93 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG300+5%Tween80+50%ddH2O	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.35 mL	131.75 mL	263.5 mL
0.5 mM	5.27 mL	26.35 mL	52.7 mL
1 mM	2.64 mL	13.18 mL	26.35 mL
5 mM	0.53 mL	2.64 mL	5.27 mL

*The above data is based on the productmolecular weight 379.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.