LDE225 (NVP-LDE225, Sonidegib)

Catalog No. A10520

LDE225 (NVP-LDE225)是一种强效、选择性和口服生物可利用的平滑(SMO)拮抗剂，通过平滑受体(SMO)的拮抗作用抑制hedgehog (Hh)信号通路。

Product Citations

Daniel Doheny, .et al. Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis, Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154

Technical details

Catalog Num	A10520
M. Wt	485.5
Formula	C26H26F3N3O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	956697-53-3
Synonyms	LDE-225
SMILES	C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F

Biological Activity

LDE225 (NVP-LDE225)是一种强效、选择性和口服生物可利用的平滑(SMO)拮抗剂，通过平滑受体(SMO)的拮抗作用抑制hedgehog (Hh)信号通路。

Targets

Smo (mouse) (Cell-free assay)	Smo (human) (Cell-free assay)
1.3 nM	2.5 nM

Solubility *

In vitro (25°C)	DMSO	82 mg/mL (168.89 mM)
	Water	Insoluble
	Ethanol	Warmed: 82 mg/mL (168.89 mM)
In vivo	2% DMSO+corn oil	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.6 mL	102.99 mL	205.97 mL
0.5 mM	4.12 mL	20.6 mL	41.19 mL
1 mM	2.06 mL	10.3 mL	20.6 mL
5 mM	0.41 mL	2.06 mL	4.12 mL

*The above data is based on the productmolecular weight 485.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.