Letrozole

Catalog No. A10523

Letrozole是芳香酶抑制剂。CGS 20267是一种新型的非甾体化合物，在体外（IC50为11.5 nM）和在体内（ED50为1-3μg/ kg p.o.）均能有效抑制芳香化酶。

Product Citations

WEI LIU, .et al. Randomized controlled trial comparing letrozole with laparoscopic ovarian drilling in women with clomiphene citrate-resistant polycystic ovary syndrome, Exp Ther Med, 2015, Oct; 10(4): 1297-1302 PMID: 26622481

Technical details

Catalog Num	A10523
M. Wt	285.3
Formula	C17H11N5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	112809-51-5
Synonyms	CGS 20267, Femara, Piroxicam
SMILES	C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3

Biological Activity

Letrozole是芳香酶抑制剂。CGS 20267是一种新型的非甾体化合物，在体外（IC50为11.5 nM）和在体内（ED50为1-3μg/ kg p.o.）均能有效抑制芳香化酶。

Targets

Aromatase (Cell-free assay)
0.07 nM-20 nM

Solubility *

In vitro (25°C)	DMSO	50 mg/mL (175.25 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% CMC Na	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.05 mL	175.25 mL	350.51 mL
0.5 mM	7.01 mL	35.05 mL	70.1 mL
1 mM	3.51 mL	17.53 mL	35.05 mL
5 mM	0.7 mL	3.51 mL	7.01 mL

*The above data is based on the productmolecular weight 285.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.