LY2886721

Catalog No. A10543

LY2886721是一种有效的，选择性的，口服活性的β位淀粉样蛋白前体蛋白裂解酶 1 (BACE1) 抑制剂。LY2886721是一种新型强效药物，用于治疗阿尔茨海默病的研究。

Product Citations

Naomi Ito, .et al. miR-15b mediates oxaliplatin-induced chronic neuropathic pain through BACE1 down-regulation, Br J Pharmacol, 2017, Mar; 174(5): 386-395 PMID: 28012171

Technical details

Catalog Num	A10543
M. Wt	390.4
Formula	C18H16F2N4O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1262036-50-9
Synonyms	LY-2886721
SMILES	C1[C@H]2CSC(=N[C@]2(CO1)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)F)F)N

Biological Activity

Targets

BACE

Solubility *

In vitro	DMSO	9 mg/mL (23.05 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.61 mL	128.07 mL	256.15 mL
0.5 mM	5.12 mL	25.61 mL	51.23 mL
1 mM	2.56 mL	12.81 mL	25.61 mL
5 mM	0.51 mL	2.56 mL	5.12 mL

*The above data is based on the productmolecular weight 390.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.