MLN8054

Catalog No. A10601

MLN8054是一种有效的，选择性Aurora A抑制剂，在Sf9昆虫细胞中IC50为4 nM，作用于Aurora A比作用于Aurora B选择性高40倍，可在体内和体外诱导人肿瘤细胞衰老。

Technical details

Catalog Num	A10601
M. Wt	476.9
Formula	C25H15ClF2N4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	869363-13-3
Synonyms	MLN-8054
SMILES	C1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)O

Biological Activity

MLN8054是一种有效的，选择性Aurora A抑制剂，在Sf9昆虫细胞中IC50为4 nM，作用于Aurora A比作用于Aurora B选择性高40倍，可在体内和体外诱导人肿瘤细胞衰老。

Targets

Target	Value
AuroraA	IC50: 4nM
AuroraB	IC50: 172nM
LCK	IC50: 3.2μM
PKA	IC50: 19μM
CK2	IC50: 20.5μM
Chk2	IC50: 28μM
PLK1	IC50: 53μM
Chk1	IC50: >100μM
PKC	IC50: >100μM
CaMKII	IC50: >100μM
CDK2E	IC50: >100μM
CDK1	IC50: >100μM

Solubility *

In vitro (25°C)	DMSO	91 mg/mL (190.82 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	15% Captisol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.97 mL	104.84 mL	209.69 mL
0.5 mM	4.19 mL	20.97 mL	41.94 mL
1 mM	2.1 mL	10.48 mL	20.97 mL
5 mM	0.42 mL	2.1 mL	4.19 mL

*The above data is based on the productmolecular weight 476.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.