MLN9708

Catalog No. A10602

MLN9708是一种蛋白酶体抑制剂，可抑制蛋白酶体的活性，从而阻断通常由蛋白酶体进行的靶向蛋白水解。

Technical details

Catalog Num	A10602
M. Wt	517.1
Formula	C20H23BCl2N2O9
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1201902-80-8
Synonyms	MLN-9708
SMILES	B1(OC(=O)CC(O1)(CC(=O)O)C(=O)O)[C@H](CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl

Biological Activity

MLN9708是一种蛋白酶体抑制剂，可抑制蛋白酶体的活性，从而阻断通常由蛋白酶体进行的靶向蛋白水解。

Targets

20S proteasome (Cell-free assay)	20S proteasome (Cell-free assay)
0.93 nM(Ki)	3.4 nM

Solubility *

In vitro (25°C)	DMSO	85 mg/mL (164.36 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% hydroxyethyl cellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.34 mL	96.69 mL	193.39 mL
0.5 mM	3.87 mL	19.34 mL	38.68 mL
1 mM	1.93 mL	9.67 mL	19.34 mL
5 mM	0.39 mL	1.93 mL	3.87 mL

*The above data is based on the productmolecular weight 517.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.