Nebivolol HCl

Catalog No. A10630

Nebivolol hydrochloride是β1-肾上腺素受体的高度选择性拮抗剂（Ki = 0.88 nM，β2-肾上腺素受体Ki = 48 nM）。

Product Citations

Giovanni Bocci, .et al. Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19, ACS Pharmacol Transl Sci, 2020, Oct 14

Technical details

Catalog Num	A10630
M. Wt	441.9
Formula	C22H25F2NO4.HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	152520-56-4
Synonyms	R-67145
SMILES	C1CC2=C(C=CC(=C2)F)O[C@H]1[C@H](CNC[C@@H]([C@@H]3CCC4=C(O3)C=CC(=C4)F)O)O.Cl

Biological Activity

Nebivolol hydrochloride是β1-肾上腺素受体的高度选择性拮抗剂（Ki = 0.88 nM，β2-肾上腺素受体Ki = 48 nM）。

Targets

β1-adrenoceptor
0.8 nM

Solubility *

In vitro	DMSO	81 mg/mL (183.3 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.63 mL	113.15 mL	226.3 mL
0.5 mM	4.53 mL	22.63 mL	45.26 mL
1 mM	2.26 mL	11.31 mL	22.63 mL
5 mM	0.45 mL	2.26 mL	4.53 mL

*The above data is based on the productmolecular weight 441.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.