Pemetrexed disodium (Alimta)

Catalog No. A10707

Pemetrexed disodium (Alimta)是一种新型抗叶酸和抗代谢药物，作用于TS，DHFR和GARFT。

Technical details

Catalog Num	A10707
M. Wt	471.4
Formula	C20H19N5Na2O6
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	150399-23-8
Synonyms	LY-231514, LY231514
SMILES	C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]

Biological Activity

Pemetrexed disodium (Alimta)是一种新型抗叶酸和抗代谢药物，作用于TS，DHFR和GARFT。

Targets

TS (Cell-free assay)	DHFR (Cell-free assay)	GARFT (Cell-free assay)
1.3 nM(Ki)	7.2 nM(Ki)	65 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	Insoluble
	Water	87 mg/mL (184.56 mM)
	Ethanol	Insoluble
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.21 mL	106.07 mL	212.13 mL
0.5 mM	4.24 mL	21.21 mL	42.43 mL
1 mM	2.12 mL	10.61 mL	21.21 mL
5 mM	0.42 mL	2.12 mL	4.24 mL

*The above data is based on the productmolecular weight 471.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.