Pirarubicin

Catalog No. A10735

Pirarubicin是蒽环类抗肿瘤阿霉素的类似物。插入DNA中并与Topo II（拓扑异构酶II）相互作用并抑制DNA复制。

Product Citations

Krishna K Ramajayam, .et al. Selecting ideal drugs for encapsulation in thermosensitive liposomes and other triggered nanoparticles, Int J Hyperthermia, 2022, 39(1):998-1009 PMID: 35876089

Technical details

Catalog Num	A10735
M. Wt	627.64
Formula	C32H37NO12
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	72496-41-4
Synonyms	THP-Adriamycin
SMILES	C[C@@H]1[C@@H]([C@@H](C[C@H](O1)OC2C[C@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O[C@@H]6CCCCO6

Biological Activity

Pirarubicin是蒽环类抗肿瘤阿霉素的类似物。插入DNA中并与Topo II（拓扑异构酶II）相互作用并抑制DNA复制。

Targets

Topo II

Solubility *

In vitro	DMSO	6 mg/mL (9.56 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.93 mL	79.66 mL	159.33 mL
0.5 mM	3.19 mL	15.93 mL	31.87 mL
1 mM	1.59 mL	7.97 mL	15.93 mL
5 mM	0.32 mL	1.59 mL	3.19 mL

*The above data is based on the productmolecular weight 627.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.